4-氨基苯甲酸的合成工艺研究

摘要

以苯胺为原料,经酰基化、碘仿两步反应合成得到了目标产物4-氨基苯甲酸,并采用IR、1H NMR和13C NMR对产物结构进行了表征.探讨了酰基化反应时催化剂AlCl3用量、反应温度和反应时间对4-氨基苯乙酮产率的影响,以及碘仿反应中反应温度、反应时间和滴加4-氨基苯乙酮速率对产物产率的影响.在最佳合成条件下,4-氨基苯甲酸的产率可达94.0％.%The target compound 4-amino benzoic acid was synthesized through acylation and iodoformation reactions with aniline as raw material.It was characterized by IR,1 H NMR and 13C NMR techniques.The influences of dosage of catalyst AlCl3,reaction temperature and reaction time on the yield of intermediate 4-amino acetophenone were investigated in the acylation reaction.The effects of reaction temperature,reaction time and dropwise rate of 4-amino acetophenone on the yield of 4-amino benzoic acid were studied in the iodoformation reaction process.The yield of 4-amino benzoic acid was 94.0％ under the optimal conditions.