膀胱癌患者手术前后机体氧化应激改变及意义

摘要

目的 探讨膀胱癌患者手术前后机体氧化应激变化及临床意义.方法 173例膀胱癌患者入选研究,其中移行上皮癌163例,腺癌5例,鳞癌4例,肉瘤1例;非肌层浸润性膀胱癌121例,肌层浸润性膀胱癌52例.分别检测手术前后患者血清VitC、VitE、超氧化物歧化酶(SOD)、谷胱苷肽过氧化物酶(GPx)、丙二醛(MDA)、总抗氧化活性(AOA)等.结果 非肌层浸润性膀胱癌患者血清VitC、VitE、SOD、GPx均明显低于肌层浸润性膀胱癌,P＜0.05,MDA含量高于肌层浸润性膀胱癌,P＜0.05.手术后患者血清VitC、VitE、SOD、GPx、AOA均明显高于手术前(P＜0.05),但MDA含量明显低于手术前(P＜0.05).结论 膀胱癌患者机体氧化应激随其恶性程度升高而升高,手术治疗后机体氧化应激水平降低.%Objective To assess the change of oxidative stress before and after operation in patients with bladder carcinoma, and to correlate these changes with the severity of the disease. Methods 173 patients with bladder carcinoma were included in the study, including 163 cases of transitional cell carcinoma, 5 adenocarcinoma, 4 squamous cell carcinoma, and 1 sarcoma. 121 cases were non-muscle invasive bladder tumors, and 52 were muscle invasive bladder tumors. Vitamin C and E, superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA), and total antioxidant activity (AOA) were estimated before and after operation. Results There were significant differences in vitamin C and E, SOD and GPx between the patients with muscle and non-muscle invasive bladder tumors (P<0. 05), and the serum MDA level of non-muscle invasive bladder tumors was higher than that of muscle invasive bladder tumors (P<0. 05). The serum levels of vitamin C and E, SOD, GPx and AOA were significantly higher (P<0. 05) while serum MDA levels were significantly lower (P<0. 05) after operation. Conclusions The oxidative stress of bladder carcinoma increased with the severity of the disease, and the level of oxidative stress reduced after operation.