血清C-反应蛋白联合降钙素原检测诊断肝癌患者介入术后感染的价值

摘要

Objective:To study the value of serum procalcitonin and C-reactive protein in monitoring the infec-tion rate of interventional operation in patients with hepatocellular carcinoma,and to provide reference for clinical di-agnosis and treatment.Methods:From October 2011 to October 2017,134 cases of liver cancer patients with interven-tional operation were selected as experimental group,and 120 cases of non infected patients were selected as control group.Two groups of patients were determined by C -reaction protein immunoturbidimetric assay,determination of procalcitonin in the electrochemical luminescence method,compared the serum C-reactive protein and procalcitonin C-content,C-reactive protein and procalcitonin positive rate,C-reactive protein combined with procalcitonin diag-nostic sensitivity and specificity.Results:Procalcitonin and C-reactive protein content in experimental group were higher than the control group,and the difference was statistically significant (P＜0.05).Experimental group of pro-calcitonin and C-reactive protein positive rates were higher than the control group,and the difference was statistically significant (P＜0.05).Procalcitonin and C-reactive protein sensitivity and the specificity is superior to single diag-nosis,and the difference was statistically significant (P＜0.05).Conclusion:In patients with hepatocellular carcino-ma after interventional operation infection,serum procalcitonin and C-reactive protein levels increased significantly.The sensitivity and specificity of combining procalcitonin with C-reactive are higher,can provide important reference for clinical diagnosis and treatment.%目的:研究血清降钙素原与C-反应蛋白联合监测肝癌患者介入手术感染价值,为临床诊治提供参考.方法:选取我院于2011年10月至2017年10月期间收治的肝癌介入手术感染患者134例为试验组,另选同期未感染患者120例作为对照组.两组患者均采用免疫比浊法测定C-反应蛋白含量,采用电化学发光法测定降钙素原含量,对比其血清C-反应蛋白和降钙素原含量、C-反应蛋白及降钙素原阳性率、C-反应蛋白联合降钙素原诊断灵敏度和特异度.结果:试验组血清降钙素原及C-反应蛋白含量均高于对照组,差异有统计学意义(P＜0.05);试验组降钙素原及C-反应蛋白阳性率均高于对照组,差异有统计学意义(P＜0.05);降钙素原联合C-反应蛋白的诊断灵敏度及特异度优于单项诊断,差异有统计学意义(P＜0.05).结论:肝癌患者介入手术感染后血清降钙素原及C-反应蛋白含量升高明显,若联合降钙素原及C-反应蛋白诊断,其灵敏度及特异度更高,可为临床诊治提供重要参考.