中晚期肝癌术前应用肝动脉化疗栓塞治疗的临床研究

摘要

Objective:To study the effect of preoperative hepatic artery chemoembolization in advanced hepatocellular carcinoma resection. Methods: Total of 100 patients treated with preoperative interventional therapy ( intervention group ) and the other 100 cases,as the control group ( no intervention group ) were compared for cumulative survival rate and survival rate. Results: In the intervention group and not intervention group 1,2 survival rates were significantly different ( P ＜ 0.05 ); intervention group 1,2 year survival rate ( 83％ ,62％ ) also higher than in the intervention group ( 47 ％ , 33 ％ ), postoperative cumulative survival rate between the two groups was statistically significant ( P ＜ 0.05 ). In the intervention group there were no complications associated with interventional treatment of liver and kidney toxicity. Conclusion: For advanced hepatocellular carcinoma accompanied by preoperative TACE treatment can significantly improve the survival rate after surgery and reduce recurrence.%目的:研究中晚期肝细胞性肝癌切除术前应用肝动脉化疗栓塞治疗是否能够降低术后复发及提高患者生存率.方法:100例术前辅以介入治疗(介入组),另外100例作为同期对照组(未介入组),比较两组的累计生存率和无瘤生存率.结果:介入组和未介入组1、2年无瘤生存率比较差异有统计学意义(P＜ 0.05);介入组1、2年生存率(83%、62%)亦高于未介入组(47%、33%),两组术后累计生存率比较差异有统计学意义(P＜0.05).介入组患者均未出现与介入治疗相关的肝、肾毒性或影响手术的不良反应.结论:中晚期肝细胞性肝癌术前辅以肝动脉化疗栓塞治疗可显著提高术后生存率,减少复发.