microRNA在结直肠癌中的研究进展

摘要

microRNA(miRNA)是一类长21-25nt核苷酸的内源性非编码调控RNA,通过与靶细胞mRNA的3'UTR完全互补导致mRNA降解,或不完全互补结合阻断mRNA翻译,参与细胞发育、增殖、分化和凋亡.miRNA具有癌基因和抑癌基因的作用,若干miRNA直接或间接参与结直肠癌的发生和发展,miRNA表达谱与结直肠癌的诊断、分期、进展和预后密切相关.%microRNA is a kind of the endogenous non - coding RNA of regulation with 21 - 25ut long nucleotide,through fully complementary with the 3 UTR of target cells mRNAlead to mRNA degradation, or not fully complementary with mRNA block mRNA translation, to involve in cell growth, proliferation, differentiation and apoptosis. miRNA are oncogenes and tumor suppressor genes, some miRNA directly or indirectly involve in the development and progression of colorectal cancer, the expression profiling of miRNA is closely related with the diagnosis, staging, progression and prognosis of colorectal cancer.