血流能量图及微血管密度与乳腺癌腋窝淋巴结转移的相关性

摘要

Objective : To explore the correlation hetween angiogenesis and axillary lymphnode metastasis in primary breast carcinoma. Methods: All 74 patients underwent Power Doppler Imaging( PDI )for categorizing the blood grades before operation. Microvessel density( MVD )was immunohistologically stained and measured with CD34 and VEGF. Axillary lymphnode metastasis was examined in pathology specimens. Results : Blood signal grade was between 2 and 3 in the 43 LN＋ , blood flow was mainly distributed in the mass surrounding as a paw distrihution. Blood signal was more rich in the LN＋ group than LN- group. The mean MVD was higher in LN＋ group than LN- group. MVD value along with blood stream grading heighten and mass volume increases while the measured values heighten. Along with blood signal and the tumor volume increased the MVD increased P ＜ 0. 05 ). With pathology grade increased the MVD increased( P＜ 0. 05 ). Conclusion : Blood signal and MVD closely related to axillary lymphnode metastasis. PDI and MVD have important value as a indicator in axillary lymphnode metastasis of primary breast carcinoma.%目的:探讨血流能量图angio(Power Doppler Imaging,PDI)及微血管密度(microvessel density,MVD)与乳腺癌腋淋巴转移的相关性.方法:术前观察74例乳腺癌的血流信号及血流能量图特征;术后标本采用免疫组化检测癌巢内MVD值,比较PDI与MVD两种方法与乳腺癌腋淋巴结转移的关系.结果:43个有腋淋巴结转移(LN+)组肿块以Ⅱ、Ⅲ级血流为主,血流主要分布在肿块周边多呈"爪"分布,血流信号较无腋淋巴结转移(LN-)组31个肿块明显丰富(P＜0.05＝.LN+组MVD值＞ LN-组(P＜0.05＝.癌巢内MVD值随Adler血流分级的增高和肿块体积的增大而测值增高(P＜0.05 ＝,且随组织学级别的增加而显著增大(P＜ 0.05).结论:乳腺癌的PDI及MVD值与腋淋巴结转移密切相关,二者结合可作为评估乳腺癌患者预后的重要指标.