淋巴结转移瘤细胞与原发灶瘤细胞的药物敏感性相关性分析

摘要

目的:研究淋巴结转移的肿瘤细胞与原发灶的肿瘤细胞是否具有一致的化疗药敏感谱.方法:比较20例非小细胞肺癌患者的原发灶与淋巴结转移灶的肿瘤细胞对5-氟尿嘧啶,丝裂霉素,顺铂,氨甲喋呤,紫杉醇等五种化疗药物的敏感性.结果:患者对各化疗药的敏感性差异很大.但是同一患者的淋巴结转移瘤细胞与原发灶瘤细胞的化疗药敏感谱相似,淋巴结转移瘤细胞与原发灶瘤细胞对顺铂的敏感性高度相关(r=0.73).结论:淋巴结转移瘤细胞可以替代原发灶瘤细胞进行药敏测试,这对于原发灶不明或者取样困难的病例具有重要意义.%Objective: To study wether the metastatic tumor cells were sensitive to the same chemotherapeutics with the primary tumor cells. Methods: Sensitivity to 5 - Fluorouracil ( 5 - FU ), mitomycin, cis - diamminedichloroplatinum( DDP ), methotrexate ( MTX ) and paclitaxel were compared between metastatic tumor cells and primarytumor cells in 20 non - small - cell lung cancer cases. Results: Although the sensitivities to the same drug varied greatly in patients, the sensitivities of metastatic tumor cells and primry tumor cells were associated ( R= 0.73 ). Conclusion: Lymph node metastatic tumor ceils can replace the primary tumor to be used in drug sensitivivty test when primary tumor is uncertain or un - acquirable.