目的:观察奈达铂胸腔灌注联合热疗治疗肺癌胸腔积液的疗效、生活质量和不良反应.方法:确诊为肺癌恶性胸腔积液的患者50例,随机分成两组,采用中心静脉导管胸腔闭式引流排尽胸水后,A组(26例)给予胸腔灌注奈达铂化疗,随后进行患侧胸腔深部热疗;B组(24例)只给予胸腔灌注奈达铂化疗.结果:A组控制胸水的有效率为88.4%,B组为62.5%(P＜0.05);A组与B组的生活质量好转率分别为84.6%和50.0%(P＜0.05).结论:采用热疗联合奈达铂胸腔灌注治疗肺癌恶性胸腔积液疗效确切,不良反应小,安全性高.%Objective:To investigate the efficacy, quality of life and side effects of thermotherapy joint with nedaplatin pleural reperfusion lung cancer pleural effusion. Methods: Patients diagnosed with lung cancer with malignant pleural effusion 50 cases were randomly divided into two groups. The treatment group( 26 cases ) were treated with nedaplatin into thoracic cavity and received concurrent hyperthemia. The control group( 24 cases ) were treated with nedaplatin alone. Results: The response rates of treatment group were 88.4％, and 62.5％ for the control group( P ＜ 0.05 ). The treatment group and control group's quality of life improvement rates were 84.6％ and respectively( P ＜ 0.05 ). Conclusion: The heat treatment to joint Nedaplatin pleural reperfusion malignant pleural effusion of lung cancer has definite effect and adverse reaction is small.
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