GFP方案分周疗法治疗晚期食管癌的临床观察

摘要

目的:探讨吉西他滨(GEM)联合氟尿嘧啶(5-FU)、顺铂(DDP)组成的GFP分周方案治疗晚期食管癌的客观疗效及安全性.方法:62例晚期食管癌,采用GFP分周方案化疗,吉西他滨(GEM)1.0g/m2,静脉滴注,第1天和第8天;氟尿嘧啶1000mg/m2持续48小时静脉滴注,第1-2和第8-9天,顺铂20mg/m2,静脉滴注,第1-2和第8-9天.每3周重复,化疗2个周期后评价疗效及不良反应.结果:62例患者共接受362周期的化疗,全部患者均可评价疗效.总有效率(CR+PR)54.8%(34/62例),中位TTP5.2个月,中位生存时间10.4个月,主要不良作用为贫血、白细胞和血小板III度和IV度下降,恶心呕吐,腹泻乏力黏膜炎等,均能耐受.结论:GFP方案分周疗法治疗晚期食管癌,疗效肯定,安全性好,患者可耐受.%Objective:To evaluate the efficacy and safety of weekly gemcetabine combined with 5 - FU/DDP in advanced esophageal cancer. Methods: Sixty - two patients with advanced esophageal cancer were treated with gemcitabine1. 0g/m2 , on days1, 8; 5 - FU 1000mg/m2 48 - hour continuously intravenous infusion on 1 -2 and the 8 -9th day, DDP 20mg/m2 , vein drop on1 -2nd and the 8 -9th day. Every three week redundant. Results:A total of 62 patients received 362 cycles of chemotherapy, all the patients can be evaluated. total response rate( CR + PR ) 54.8 ％ ( 34/62 example ), median TTP 5.2 month, mOS 10.4 months. The main side effect were anemia, leukopenia and thrombocytopenia of grade 3 - 4, vomit, diarrhea , asthenia, mucous membrane inflammation. Conclusion: We GFP plan weekly therapy for advanced esophagus cancer, the curative effect is good.