Objective : To analyze the clinicopathological features, prognostic factors of the patients with triple negative breast cancer , and find out effective treatment. Methods : Clinical Data of 510 patients with histopathologically confirmed resectable breast cancer from 2000 to 2005 were analyzed. Of the 510 patients, 108( 21. 2％ ) were confirmed to be triple - negative breast cancer. The clinical characteristics, local recurrence or distant metastasis, overrall survival of the patients were compared between the triple - negative breast cancer and non - triple negative breast cancer group. Results : Of 510 patients , 108( 21. 2％ ) had triple negative breast cancer. The rate of local or recurrence or distant metastasis for 5 years in the triple negative breast cancer group( 30. 8％ ) was higher than that in the non - triple negative breast cancer group( 18. 7％ , P ＜ 0. 05 ). The 5 - year overrall survival in the triple negative breast cancer group( 78. 4％ ) was lower than that in non - triple negative hreast cancer group( 88. 1％ , P ＜ 0. 05 ). Conclusion : Triple negative breast cancer has unique clinicopathological features. Compared with non - triple negative breast cancer, it has an increased possibility of local recurrence and distant metastasis, leading a poorer prognoSiS.%目的:分析三阴性乳腺癌的临床病理学特征及其影响预后的因素,探索更为有效的治疗方案.方法:收集2000年1月至2005年9月收治的经病理组织学证实、有完整随访资料的510例可手术乳腺癌患者的临床资料,108例(21.2%)患者证实为三阴乳腺癌.比较三阴乳腺癌组与非三阴乳腺癌组的临床特征、复发或远处转移、生存情况.结果:510例患者中108例患者是三阴性乳腺癌,其组织学III级、髓样癌的比例明显高于非三阴性乳腺癌(P＜0.05).三阴性乳腺癌的5年复发或远处转移率(30.8%)明显高于非三阴性(18.7%,P＜0.05).三阴性乳腺癌的5年总生存率(78.4%)明显低于非三阴性(88.1%,P＜0.05).结论:三阴性乳腺癌具有独特的临床病理特征,比非三阴性乳腺癌更易发生局部复发和远处转移,预后较差.
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