Survivin和Runx3蛋白在胃癌组织中的表达及其临床意义

摘要

Objective:To study the expression and clinical significance of Survivin and Runx3 in gastric carcinoma tissue. Methods: The expressions of Survivin and Runx3 were detected by SP immunohistochemical technique in 52 cases of gastric carcinoma and analyze the relationship between the expression of Survivin, Runx3 and the clinicopathological character of samples. Results: The expression rate of Runx3 in gastric cancer was low ( 53.8％ ), and reduced with the increased invasive depth and occurrence of lymphatic metastasis,long -distance metastasis and clinical stages ( P ＜ 0.05 ). The expression rate of Survivin in gastric cancer was high ( 75.9％ ), and elevated with the increased invasive depth, occurrence of lymphatic metastasis and clinical stages( P ＜ 0.05 ). Conclusion: The over -expression of Survivin and low - expression of Runx3 may play a role in the pathogenesis of gastric carcinoma,combined detection would be of benefit in selecting chemotherapeutic agents and evaluating prognosis in gastric carcinoma.%目的:探讨Survivin和Runx3蛋白在胃癌组织中的表达情况及临床意义.方法:应用免疫组织化学 SP法检测52 例手术切除胃癌组织中 Survivin 和Runx3蛋白的表达水平,分析二者的表达与临床病理特征之间的关系.结果:胃癌组织中Runx3阳性表达率53.8%,与胃癌的肿瘤浸润深度 、淋巴转移、远隔转移、临床分期呈负相关(P<0.05).胃癌组织中Survivin阳性表达率78.8%,与胃癌的肿瘤浸润深度、淋巴转移、临床分期呈正相关(P<0.05).结论:在胃癌组织中Survivin高表达、Runx3低表达与胃癌的发生发展密切相关,联合检测Survivin和Runx3蛋白对于胃癌的治疗具有指导意义,也可作为判断胃癌预后的参考指标.