Objective : To investigate the changes of tumor suppressor gene PTEN encoding product in gastric adenocarcinoma and gastric polyp. Methods: Samples of gastric adenocarcinoma and gastric polyp were collected from endoscopy center and oncology surgery department of China Medical University . The gastric polyp group was divided into inflammatory polyp, proliferative polyp and adenomatous polyp,60 cases in each group. PTEN protein expression was detected by S - P immunohistochemistry. Results : The protein expression of PTEN in normal gastric mucosa was 100％ , in inflammatory polyp , proliferative polyp and adenomatous polyp , the protein expression of PTEN was 98. 3％ , 91. 6％ , 78. 3％ respectively. For gastric adenocarcinoma, PTEN protein expression was 61. 6％ . There was statistically difference between inflammatory polyp , proliferative polyp and adenomatous polyp( P ＜ 0. 05 ),also, there was statistically difference between gastric adenocarcinoma and adenomatous polyp( P ＜ 0. 05 ). Conclusion : PTEN protein was downregulated in inflammatory polyp, proliferative polyp, adenomatous polyp and gastric adenocarcinoma.%目的:探讨胃息肉和胃腺癌中抑癌基因PTEN编码产物的变化.方法:选取中国医科大学附属一院内镜中心活检标本和肿瘤外科术后大体标本,其中炎性息肉、增生性息肉、腺瘤型息肉、胃腺癌,每组60例,SP 免疫组化检测PTEN基因编码产物的表达.结果:PTEN蛋白质表达在正常胃黏膜为100%,在炎性息肉、增生性息肉、腺瘤型息肉PTEN蛋白质的表达分别为 98.3%,91.6%,78.3% ;在胃腺癌中PTEN蛋白质的表达为61.6%.炎性息肉、增生性息肉和腺瘤型息肉之间差异有统计学意义(P<0.05),腺瘤型息肉与胃腺癌之间差异有统计学意义(P<0.05).结论:在炎症性息肉、增生性和腺瘤型息肉以及胃腺癌中,PTEN蛋白呈下调性表达.
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