原发性肝癌三维适形放射治疗后长期生存1例报告及文献复习

摘要

Objective: To investigate tumor regression speed of hepatocellular carcinoma and the variation characteristics of liver shape size, AFP and liver fuction after three - dimensional conformal radiotherapy, and analyze the radiation dose and dose fractionation.Methods : One case of hepatocellular carcinoma after three - dimensional conformal radiotherapy was followed - up and the related literature was renewed.Results : Significant tumor regression was observed three months after three - dimensional conformal radiotherapy, the tumor may be observed to regress two years three - dimensional conformal radiotherapy.Conclusion : Radiosensitivity of hepatocellular carcinoma is equal to low differentiated squamous cell carcinoma, the tumor of hepatocellular carcinoma may continu to regress in two years after three - dimensional conformal radiotherapy.Patients with small - sized hepatocellular carcinoma whose liver fuction are child - pugh grade A treated with HORT is one of safe and effective local treatments.%目的:探讨三维适形放疗后原发性肝癌肿瘤退缩速度及肝脏大小形态、AFP及肝功等方面变化特征,并分析放疗剂量及分割方式.方法:对1例原发性肝癌三维适形放疗后长期随访,并复习文献.结果:原发性肝癌在放疗后3个月肿瘤明显退缩,放疗后2年内病灶仍可继续缩小.大 分割放疗方案在肝功能Child-pugh A级及病灶较小的病人中实施耐受性好、安全有效.结论:原发性肝癌的放射敏感性相当于低分化鳞癌,放疗后2年内病灶仍可继续缩小 .大分割放疗方案在肝功能好病灶较小的病人中实施较安全.