大肠鳞状细胞癌的临床病理特征(附1例报道并文献复习)

摘要

目的:探讨大肠鳞状细胞癌的临床表现、病理形态特征、治疗及预后.方法:对1例直肠鳞状细胞癌病例进行组织形态学、免疫组织化学分析结合原位杂交HPV16/18检查,并复习相关文献.结果:大肠鳞状细胞癌常见于40-50岁年龄组患者,男性略多,多见于乙状结肠和直肠,形态学表现为不同分化程度的鳞状细胞癌,表达鳞状细胞癌标记如p63,CK5/6;个别病例可见HPV16感染.结论:大肠鳞状细胞癌是一种罕见病变,临床表现与常见的腺癌相似,外科手术为最有效的治疗,预后较腺癌差;有时内窥镜镜下易与间质瘤误诊.%Objective :To investigate the clinic - pathological features, diagnosis and prognosis of intestinum crasaum suqamous cell carcinoma( scc) .Methods : A case of intestinum crassum suqamous cell carcinoma was reported,based on histological and immunohistochemical studies and the literature wae reviewed.Results : Primary intestinum crassum suqamous cell caranoma occur most commonly in the fifth decade of life with a slight predominance for men.The tumors histologic appearances was well or poorly differentiation , tumor cell showed positive for p63 and CK5/6;HPV16 was detected in a few of cases.Conclusion : Intestinum crassum scc is a rare tumor with an aggressive course ;clinical features are similar with adenocarcinoms, the prognosis is worse; surgery is the most effective therapy, and adjuvant chemotherapy and radiotherapy shoould be considered ; sometimes.