目的:探讨培美曲塞二线治疗老年晚期非小细胞肺癌的疗效及不良反应.方法:老年晚期非小细胞肺癌患者34例,采用培美曲塞500 mg/m2,静脉滴注,第1天；21d为1周期,至少2周期后评价疗效.结果:有效率(RR)为14.7％,中位TTP 3.2个月,中位生存期7.9个月.主要毒副反应为骨髓抑制及消化道反应.结论:培美曲塞二线治疗老年晚期非小细胞肺癌的近期疗效较好,且患者耐受性好,值得临床推广.%Objective: To evaluate the efficacy and the side - effects of pemetrexed as second - line treatment of elderly patients with advanced non — small cell lung cancer. Methods: Thirty — four elderly patients with advanced non — small cell lung cancer accepted the chemotherapy of pemetrexed 500mg/m on day 1. Three weeks as a circle. The efficacy and the side - effects were evaluated at least after two circles. Results: The total effective rate was 14.7%. The median time to progress was 3. 2 months and the median survival was 7. 9 months. The main side -effects were myelosuppression, nausea and vomiting. Conclusion: Pemetrexed in the second line of treatment of elderly patients with advanced non - small cell lung cancer is effective and with low side - effects.
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