STAT-3 和 MGMT 在人胶质瘤中的表达及意义

摘要

目的:探讨STAT3和MGMT在人胶质瘤中的表达及其与肿瘤发生和病理分级之间的关系.方法:用免疫组化法检测并比较80例不同病理级别胶质瘤和15例正常脑组织中STAT3和MGMT的表达情况,并对二者表达做相关性分析.结果:STAT3和MGMT在正常脑组织中均未检测到阳性表达,在瘤组织中的表达均随肿瘤病理级别的升高而增高,相关性分析显示二者的表达存在正相关.结论:STAT3在胶质瘤的发生发展中起重要作用,其高表达可能与参与诱导MGMT的高表达有关.%Objective:To explore the expression of STAT —3 and MGMT in human gliomas and its relationship with tumorigenesis and the degrees of malignancy. Methods: Immunohistochemical SP method was employed to study the expression of STAT -3 and MGMT in 80 cases of glioma and 15 cases of normal cerebral tissue used as control group, the relationship of STAT - 3 and MGMT expression was analyzed. Results: Both the expression of STAT - 3 and MGMT increased as the malignant grade increased, at the same time the expression of STAT3 was positively related to that of MGMT. Conclusion: STAT3 may play a vital role in the progression of glioma through induction of MGMT.