辅酶Q10治疗蒽环类药物致心脏毒性的疗效

摘要

Objective:To study the protective effect of CoQl0 on the cardiovascular toxicity induced by anthracycline, and investigate the possible mechanisms. Methods: Sixty tumor patients were randomly divided into treatment group(30 cases) and control group(30 cases). Receiving chemotherapy,at the same time,CoQ10 and a large dose of vitamin E were given in two groups. Electrocardiography and cardiac enzymes were examined before and after treatment. Results: ECG and myocardial enzyme were all improved significantly in the treatment group, and the changes were superior to those of the control group ( P < 0 05 ) . Conclusion: CoQl0 had protective effects on the cardiovascular toxicity induced by anthracycline.%目的:研究辅酶Q10 (CoQ10)对使用蒽环类化疗药物致心脏毒性的保护作用,并探讨可能的机理.方法:60例肿瘤患者随机分为治疗组(30例)和对照组(30例),化疗同时分别予CoQ10及大剂量维生素E治疗,治疗前后行心电图、心肌酶检查.结果:化疗后CoQ10组心电图和血清心肌酶学指标均优于对照组(P＜0.05).结论:CoQ10对蒽环类化疗药物所致心脏毒性有保护作用.