RECK 在非小细胞肺癌中的表达及意义

摘要

目的:研究RECK在肺癌组织和非癌组织中的表达,探讨其在肺癌浸润和转移中的作用.方法:临床及病理资料完整的非小细胞肺癌组织50例,及20例非癌肺组织,采用免疫组化SP法检测RECK的表达情况.结果:RECK在肺癌组织中的表达阳性率(20％)明显低于其在非癌组织中的表达阳性率(90％),两者相比有明显的统计学差异(P＜0.001)；在肺癌组织中,RECK的表达与患者的年龄、性别、是否吸烟及吸烟量、病理类型、分化程度无明显关系,与是否有淋巴结转移(P=0.001)及TNM分期有关(P =0.034).与有淋巴结转移和TNM分期晚期(Ⅲ、Ⅳ期)的患者相比,无淋巴结转移和TNM分期早期(Ⅰ、Ⅱ期)的患者RECK的表达水平明显高.结论:RECK在肺癌组织中低表达,与肺癌的侵袭和转移密切相关.%Objective: To study the expression of reversion — inducing - cysterine — rich protein with kazal motif (RECK) in non - small cell lung cancer (NSCLC) and its effect on the invasion and metastasis of NSCLC. Methods: SP immunohistochemical method was used to detect the protein expression of RECK in 50 cases of NSCLC and 20 cases of non - cancerous lung tissues. Results: The positive expression rate of RECK in the case of NSCLC was 20% , which was lower than that in non - cancerous lung tissues (90% ) ,and the difference was statistically significant ( P <0. 001). There were significant correlations between the RECK expression and cancer lymph node invasion(P = 0. 001 ) and TNM staging ( P = 0. 034 ) , rather than age, sexuality, smoking, pathological types, or the degrees of differentiation. Compared with patients with lymph node invasion and advanced stage of TNM staging ( Ⅲ , Ⅳ stage) ,the expression rate of RECK was significantly increased in the cases with no lymph node invasion and the earlier period of TNM staging ( Ⅰ ,Ⅱ stage). Conclusion: The expression of RECK in NSCLC is lower,and is closely correlated to the invasion and metastasis.