高强度聚焦超声联合DC-CIK过继免疫治疗晚期原发性肝癌的临床研究

摘要

suffering from advanced HCC were divided into two groups randomly. 25 patients of HIFU group were treated by HI-FU only and other 25 patients of joint group were treated by HIFU and adoptive immunotherapy( dendritic cell and cy-tokine - induced killer cell, DC - CIK) . Results; After treatment, quality of life, AFP, immune functions and survival time in joint group were much better than HIFU group (P < 0.05). Conclusion: HIFU and DC - CIK have syn-ergistic therapeutic effect, HIFU plus CIK can improve curative effect of patients with advanced hepatocellular carcinoma.%目的:探讨高强度聚焦超声(HIFU)联合过继免疫治疗晚期原发性肝细胞癌(HCC)的临床疗效和应用价值.方法:选择50位诊断明确的晚期HCC患者,随机分为2组.海扶组25例,接受单纯HIFU治疗；综合组25例,除给予HIFU治疗外,还接受自身树突状细胞(DC)和细胞因子诱导的杀伤细胞(CIK)回输治疗.比较2组患者的临床疗效.结果:治疗后综合组患者的生活质量、肿瘤标志物、肝功、免疫状态、生存时间等指标均优于单纯HIFU组(P＜0.05).结论:HIFU与DC - CIK过继免疫具有协同治疗效果,HIFU联合DC- CIK能提高晚期HCC患者的临床疗效.