TSLC1在食管鳞癌中的表达及临床意义

摘要

Objective:To investigate the correlation between the TSLO protein expression and the clinical pathological parameters in esophageal squamous cell carcinoma ( ESCC) , and to explore its roles in the formation and development of ESCC. Methods: The expression of TSLC1 protein in 50 ESCC samples and 50 pericancerous normal tissues was examined by immunohistochemistry SP method. The significance of TSLC1 in the development of ESCC was analyzed. Results; TSLC1 expressed highly in pericancerous normal tissues. The positive expression rate of TSLC1 in ESCC (48% , 24/50) was significantly lower than that in pericancerous normal tissues (94% , 47/50; P <0.01). The expression of TSLC1 was correlated with infiltration degree, regional lymph node metastasis and TNM stage of esophageal carcinoma (P<0.05) , but not with gender, age, size, pathological typing, location or differentiation degree of tumor. Conclusion; TSLC1 protein may play inhibitory effect on the development of ESCC, and its expression may be related to the infiltration and metastasis of ESCC.%目的:研究食管鳞状细胞癌组织中肺癌肿瘤抑制因子1(TSLC1)基因的表达及临床病理意义,探讨其在食管鳞状细胞癌发生、发展过程中的作用.方法:应用免疫组化(SP法)检测50例食管鳞状细胞癌标本及癌旁正常食管组织中TSLC1基因的表达情况,分析其与食管鳞状细胞癌患者临床病理学参数之间的关系.结果:50例食管鳞状细胞癌组织中TSLC1基因表达阳性率为48.0％ (24/50),其表达与癌组织浸润深度、区域淋巴结转移及TNM分期有关(P＜0.05).与性别、年龄、肿瘤大体分型、肿瘤大小、位置、分化程度无关(P＞0.05).50例癌旁正常食管组织中TSLCl基因高表达,阳性率为94.0％ (47/50).食管鳞状细胞癌组织中的阳性表达率显著低于癌旁正常食管组织,两者相比差异有统计学意义(P＜0.01).结论:食管鳞状细胞癌组织中有明显的TSLC1基因的表达缺失,TSLC1蛋白表达缺失与食管鳞状细胞癌的发生、发展有关.