EGFR、Her-2和细胞周期素A在食管鳞癌中的表达

摘要

Objective:To explore the expressions of EGFR,Her -2 and CyclinA in esophageal squamous cell carcinoma (ESCC) and their relationship with clinicopathological parameters. Methods: The expressions of ECFR, Her - 2 and CyclinA were examined by immunohistochemistry (IHC) in 76 surgically obtained ESCC specimens (group ESCC) and in 21 specimens of tumor - adjacent normal squamous epithelium as the controls ( group C). Results: The expressions of EGFR(63. 2% ) , CyclinA(61. 8% ) were higher in group ESCC than those in group C (33. 3% , 23.8% ,P<0.05). In group ESCC, Her-2 expression was low in group ESCC and no expression in group C. EG-FR, Her -2 and CyclinA were correlated to vascular recidivism,lymph node metastasis. Besids,Her -2 and CyclinA were correlated to invasion of ESCC cells. Expression of EGFR and CyclinA was positive related; No relationship was found between Her - 2 and EGFR, CyclinA. Conclusion: The high expressions of EGFR and CyclinA may correlate to tumor genesis and development of esophageal carcinoma and may be a new target for targeted therapy of esophageal carcinoma; The expressions of Her-2 was low, and may be not the target of esophageal carcinoma.%目的:探讨食管鳞癌中EGFR信号传导通路相关分子(EGFR、Her -2)及细胞周期素A的表达情况及三者之间的相互关系.方法:随机选取食管鳞癌根治术后的切除标本76例和21例癌旁正常鳞状上皮组织,应用免疫组化法检测EGFR、Her -2和细胞周期素A的表达.结果:EGFR、细胞周期素A在食管鳞癌的表达明显高于癌旁正常鳞状上皮(63.2％ vs 33.3％、61.8％ vs 23.8％,P＜0.05),Her -2在食管鳞癌低表达(3.9％),正常鳞状上皮不表达；EGFR、Her -2和细胞周期素A均与脉管累犯、淋巴结转移正相关,此外,Her -2和细胞周期素A还与肿瘤浸润深度正相关；EGFR与细胞周期素A的表达成正相关(P＜0.01),而Her2与EGFR及细胞周期素A表达未发现相关关系.结论:EGFR和细胞周期素A在食管鳞癌中高表达可能与食管鳞癌的发生发展有关,并有可能成为靶向治疗的靶点,而Her -2在食管鳞癌由于表达很低,有可能不是该肿瘤分子治疗的靶点.