新疆地区汉族、维吾尔族晚期非小细胞肺癌患者血清中CEA表达的差异性研究

摘要

Objective:To investigate the difference of CEA expression in serum between Uygur and Han patients of advanced non - small cell lung cancer in advanced non - small cell lung cancer. Methods: There were 101 cases of advanced non - small cell lung cancer in the People's Hospital of Autonomous Region in recent 5 years. Among them, there were 50 cases of Uygur and 51 cases of Han patients. We detected the CEA in serum by chemiluminescent enzyme immunoassay, then compared the patients above with 50 healthy Han people and 50 healthy Uygur people in the medical examination center of our hospital. Results: The difference of CEA reached statistical significance between the Han healthy group and the group of advanced non - small cell lung cancer( P < 0.05); Neither did the difference of CEA the Uygur healthy group and the group of advanced non - small cell lung cancer( P < 0.05 ) ; The differences of CEA failed to reach statistical significance between the Uygur people and Han people in the group of stage III non - small cell lung cancer( P > 0.05 ) ; Neither did the difference of CEA in the stage IV( P > 0.05 ) ; The difference of CEA failed to reach statistical significance between the Uygur people and Han people in the group of advanced lung squamouse - cell cancer( P > 0. 05); Neither did the difference of CEA in the group of advanced lung non - squa-mouse - cell cancer(P > 0. 05 ). Conclusion: The difference of the expression of CEA reached statistical significance for the Han people and the advanced non - small cell lung cancer patients. ; Neither did the difference of CEA the Uygur healthy group and the group of advanced non - small cell lung cancer. There was no difference of the expression CEA between the Uygur people and Han people in the group of stage Ⅲ and Ⅳ non - small cell lung cancer. There was no difference of the expression of CEA between the Uygur people and Han people in the advanced lung squamouse - cell cancer and the advanced lung non - squamouse - cell cancer.%目的:通过对晚期非小细胞肺癌患者血清中CEA的监测,探讨在维吾尔族、汉族晚期非小细胞肺癌患者之间其表达是否有差异性.方法:新疆维吾尔自治区人民医院2005年5月-2010年5月确诊的晚期非小细胞肺癌患者101例,其中维吾尔族50例,汉族51例,采用全自动免疫化学发光仪检测血清CEA的水平,与我院体检中心体检合格的汉族及维吾尔族健康者各50例进行比较.结果:汉族、维吾尔族健康组CEA与同民族晚期非小细胞肺癌组CEA结果比较差异均有统计学意义(P＜0.05)；汉族Ⅲ期、Ⅳ期非小细胞肺癌组CEA与维吾尔族同期别非小细胞肺癌组CEA结果比较差异均无统计学意义(P＞0.05)；汉族与维吾尔族晚期肺鳞癌组、肺非鳞癌组CEA结果比较差异均无统计学意义(P＞0.05).结论:CEA在汉族、维吾尔族健康人群与同民族晚期非小细胞肺癌患者血清中的表达有差异；CEA在汉族与维吾尔族Ⅲ期、Ⅳ期非小细胞肺癌及肺鳞癌、肺非鳞癌患者血清中的表达无差异.