蟾蜍制剂诱导肿瘤细胞凋亡的研究进展

摘要

蟾蜍制剂是我国传统中药材,具有镇痛、消炎、麻醉等作用.近年来研究表明其具有多种抗肿瘤作用,包括诱导细胞凋亡,抑制增殖,促进细胞分化,抑制肿瘤血管形成等作用.而近几年来,以研究蟾蜍制剂诱导肿瘤细胞凋亡作用机制最多,本文主要就近几年来蟾蜍制剂:华蟾素、蟾毒灵及华蟾毒精诱导细胞凋亡作用机制的研究进展做一综述.%Venenum bufonis.as one of the traditional Chinese material medica,has functions in analgesia,eliminating inflammation,anesthesia et al. Recent studies indicated that venenum bufonis has the distinguished anticancerac-tivity. It could induce apoptosis, inhibit the cell proliferation,promote the cell differentiation,reverse the drug resistance , restrain neovacularization. This review mainly summarizes the apoptosis - inducing effects of toad preparations ( Cinobufacini, Bufalin and Cinobufagin) in recent years.