目的:探讨清得佳凝胶预防乳腺癌术后放疗致急性放射性皮肤损伤的效果.方法:收集本院病理确诊乳腺癌且行术后辅助胸壁放疗病例50例,随机分为治疗组和对照组各25例.治疗组在常规护理的基础上于第1次放疗后即给予清得佳凝胶涂抹照射野皮肤,对照组只给予常规护理,对两组皮肤损伤严重程度及相应剂量进行比较.结果:症状轻的Ⅰ级放射性皮肤反应在治疗组发生率(68％)高于对照组(12％)；症状较重的Ⅲ级皮肤反应治疗组(8％)低于对照组(28％).皮肤反应发生剂量:对照组21例(84％)出现于照射40Gy以前,治疗组仅有11例(44％),治疗组较对照组明显减轻及延缓放射性皮炎的发生(P＜0.01).结论:清得佳凝胶能有效地预防乳腺癌放疗致急性放射性皮炎的发生.%Objective: To observe the clinical efficacy of Intrasite Gel in prevention of radiation dermatitis of patients with breast cancer. Methods: All 50 patients were randomly divided into two groups;25 patients in treatment group were treated with Intrasite Gel from first time of radiotherapy; 25 patients in control group received normal therapy. The skin injury rate and related radiation dose during the radiotherapy were observed. Results: Stage I skin injury rate in the treatment group was lower than control group (8% vs 28% ) , while stage Ⅲ skin injury rate was higher than control group (68% vs. 12% ) , and it needs irradiation of higher dosage to induce skin injury. The difference was significant(P<0.01). Conclusion; Intrasite Gel can effectively prevent and relieve radiation dermatitis.
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