血清中人附睾蛋白4、抑制素A及癌胚抗原125联合检测在卵巢癌诊断中的意义

摘要

目的:探讨人附睾蛋白4(HF4)、抑制素A(inhibinA)及癌胚抗原125( CA125)在卵巢癌患者中的诊断价值.方法:应用ELISA法检测卵巢癌组、卵巢良性肿瘤组及正常对照组患者血清中HE4、InhibinA、CA125水平.结果:血清HE4水平:卵巢癌组(133.86±127.94) pmol/L、卵巢良性肿瘤组(42.67±22.77) pmol/L、正常对照组( 33.40±19.50) pmol/L；血清InhibinA水平:卵巢癌组(177.22±114.35) ng/L、卵巢良性肿瘤组(76.60±14.10)ng/L、正常对照组(70.70±21.66)ng/L;血清CAl25水平:卵巢癌组(750.52±1230.34) U/L、卵巢良性肿瘤组(67.25±106.16)U/L、正常对照组(17.69±6.13) U/L.统计学分析血清HE4、InhibinA数值显示:卵巢癌组与卵巢良性肿瘤组、正常对照组比较,P＜0.05,差异有统计学意义；而卵巢良性肿瘤组与正常对照组比较,P＞0.05,差异无统计学意义.血清CA125卵巢癌组与卵巢良性肿瘤组、正常对照组比较,P＜0.05,差异有统计学意义；良性肿瘤组与正常对照组比较,P＜O.05,差异有统计学意义.卵巢癌诊断中的阳性率分别是:HE4 71.8％、InhibinA 66.7％、CA125 61.5％,三者联合阳性率为92.3％.结论:HF4、InhibinA、CA125在卵巢癌诊断中有重要意义,三者联合检测能明显提高卵巢癌的诊断率.%Objective: To detect the level of serum human epididymis4, InhibinA and CA125 in patients with ovarian cancer. Methods: ELISA method was used to test serum HEMnhibinA and CA125 in ovarian cancer group, benign o-varian tumor group and the healthy control. Results: The serum HE4 level of ovarian cancer group was ( 133. 86 ± 127.94)pmol/L, benign ovarian tumor group was (42.67 ±22.77)pmol/L, the healthy control was (33.40 ±19.50) pmol/L; Serum InhibinA level: ovarian cancer group was ( 177. 22 ± 114.35)ng/L, benign ovarian tumor group was (76.60 ±14. 10)ng/L, the healthy control was (70.70 ±21.66)ng/L; Serum CA125 level; ovarian cancer group was (750.52 ± 1230. 34) U/L, benign ovarian tumor group was (67.25 ±106. 16)U/L, the healthy control was (17.69 ±6. 13)U/L. Serum HE4 and InhibinA: comparing with ovarian cancer group,ovarian benign tumor group and normal control group, P <0.05, and ovarian benign tumor group compared with normal control group, P >0.05. For CA125 comparing with ovarian cancer group,ovarian benign tumor group and normal control group, P < 0.05, the difference was statistically significant, benign tumor group compared with normal control group, P < 0. 05. The positive rate were; HE4 70. 59% .InhibinA 66. 7% ,CA125 63. 3% , the positive rate of combination was 93. 3%. Conclusion:HE4,InhibinA, CA125 have important significance in the diagnosis of ovarian cancer, combination of these three markers can raise up the positive rate of diagnose of ovarian cancer.