目的:探讨鼻咽癌后程三维适形放射治疗正向计划的设计及优化方法.方法:随机选取20例鼻咽癌后程加量的患者,在PROWESS PANTHER计划系统上进行三维适形放射治疗正向计划的设计及优化,通过射野数目、射野方向、射野权重因子的合理设定及选择,结合DVH图和剂量曲线分布情况选择最优方案.结果:分析患者的DVH图,显示各靶区均能达到较好的剂量曲线分布,在给予靶区致死剂量的同时,周围危及器官受量都在其耐受剂量范围内.结论:在没有开展调强放疗技术的单位,根据鼻咽癌患者病变侵犯情况,选择合适的射野进行三维适形放疗正向计划设计及优化,也能得到符合临床要求的较佳的治疗计划,从而可提高鼻咽癌局部控制率,有效保护危及器宫,提高病人的生存质量.%Objective:To investigate the plan and method of optimization of three - dimensional conformal radiotherapy (3DCRT)for nasopharyngeal carcinoma. Methods: Twenty patients with nasopharyngeal carcinoma were treated by late course 3DCRT. 3D plans were designed using PROWESS PANTHER treatment planning system. To select careful beam angle,beams number selection and beam weighting factor settings, combined with DVHs and dose curve distribution map, then choose the best option. Results: Analysis of the 20 patients' DVHs showed the targets all could be wrapped by better dose line and the surrounding organs at risk were within the scope of its tolerance dose. Conclusion: In the departments which can not carry out IMRT, to choose the right beams also can produce a high - quality 3DCRT plan, which can improve the control rate of nasopharyngeal carcinoma, protect organs at risk and improve patients quality of life.
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