目的:观察血管形成素(angiogenin,ANG)在宫颈鳞癌组织中的表达情况并探讨其临床病理意义.方法:应用免疫组化方法对48例石蜡包埋宫颈鳞癌组织切片进行ANG蛋白表达的检测,并分析其与宫颈癌患者年龄、肿瘤分化程度和浸润的关系.结果:48例宫颈癌中全部ANG蛋白免疫染色为阳性,分布部位在细胞浆和细胞核,细胞类型以癌细胞、间质成纤维细胞和血管内皮细胞表达为主.高分化组与低分化组之间(P=0.0032)、中分化组与低分化组之间ANG表达的差异有统计学意义(P=0.0265),有浸润和无浸润组之间差异有显著性(P=0.0184).结论:ANG蛋白在宫颈鳞癌中普遍表达,且表达水平与肿瘤分化程度以及浸润有关,提示ANG可能参与宫颈癌的发生发展.%Objective: To investigate expression of angiogenin( ANG ) in cervical squamous cell carcinoma and its clinical pathological significance. Methods: Expression of ANG was determined by immunohistochemical analysis in paraffin - embedded tissue sections of 48 cases of cervical squamous cell carcinoma, and the correlation between ANG expression and age, differentiation and invasion of the cases. Results: All of the cervical squamous cell carcinoma cases were positive for ANG, with cytoplasmic and nuclear immunoreactivity located in tumor cells, intratumor fibroblasts, and endothelial cells. Either of the difference of ANG expression between well - differentiation group andpoor - differentiation group ( P =0. 0032 ) or moderate - differentiation group and poor - differentiation group was significant ( P = 0.0265 ). The difference between invasion group and non - invasion group was also significant ( P = 0. 0184 ). Conclusion: Expression of ANG is common in cervical squamous cell carcinoma and correlates with tumor differentiation and invasion, suggesting that ANG may be involved in the development of cervical squamous cell carcinoma.
展开▼
