中药合剂'振明正生'对三株人肿瘤细胞裸鼠移植瘤抑制作用的观察

摘要

Objective: To observe the inhibitor effect of Chinese herbal medicine " Zhenmingzhengsheng compound" ( ZMZS ) on three models of human tumor xenograft in mice. Methods: BALB/c nude mice were inoculated three strains ol human tumor cell, including leukemia cell K562 , nasopharyngeal carcinoma and carcinoma ol pancreas, 2× l06/mouse. 24 hours after inoculated,ZMZS was administered to the experiment mice ( 0. 2ml/mouse,p. O. ), and saline to the control mice, once every day, for four weeks. The size of tumor was measured each week, and the inhibitive rate of tumor growth was calculated. Results: ZMZS showed obvious inhibitor effect in the three tumor models. The rate of inhibition was 43. 6% to 97. 0%. Conclusion: ZMZS has significant therapeutic effect on the three human tumor cell models.%目的:观察中药合剂"振明正生"(ZMZS)对人肿瘤细胞的抑制作用.方法:BALB/c裸鼠分别接种人白血病细胞系(K562)、鼻咽癌细胞系(CN1)和胰腺癌细胞系(P3),2×106/只.接种后24小时开始给药,实验组裸鼠每天口服中药合剂0.2ml/只,连续4周.对照组裸鼠口服生理盐水0.2ml/只.每周测量动物肿瘤大小,计算肿瘤生长抑制率.结果:经过3或4周的治疗,中药合剂"振明正生"对K562、CN1和P3有明显抑制作用.结论:中药合剂"振明正生"对三株人肿瘤细胞裸鼠移植瘤有显著的治疗效果.