目的:研究恶性血液病合并粒细胞缺乏患者并发深部真菌感染的临床特点.方法:回顾性分析30例粒细胞缺乏合并DFI患者的资料.结果:接受骨髓移植、多次化疗、反复应用激素及免疫抑制剂等治疗的粒细胞缺乏患者,细胞及体液免疫功能明显降低,同时长期应用广谱抗生素破坏了宿主正常菌群生态平衡,成为真菌感染的高危人群.医院内DFI的病原菌主要为白色念珠菌,占61.8%;应用rhG-CSF等药物能缩短粒缺的时间,有利于DFI的治疗.结论:粒细胞缺乏的血液病患者极易并发深部真菌感染,应尽早行保护性隔离.应及时应用rhG-CSF,缩短白细胞减少持续时间,合理使用抗生素,对高度怀疑真菌感染病灶存在时应预防性应用抗真菌治疗,适时据培养结果选用有效抗菌药物.%Objective:To study clinical features of malignant hematopathy complicated with agranulocytosis associated with deep fungal infection. Methods: Retrospective analyze the data of 30 case combined with DFI. Results: Bone marrow transplant, repeated application of multiple chemotherapy hormone and immunosuppressive agents such as treatment with neutropenia, cellular and low humoral immunity in, long - term broad - spectrum antibiotics were high risk factors. DFI pathogens in hospitals was mainly Candida albicans, 61. 8%. Conclusion: Neutropenia of deep fungal infection in patients with hematological disease, should have protective isolation; rhG - CSF application,shortening the duration of leukopenia, rational use of antibiotics are useful for patients.
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