Objective:To explore the clinicopathological features for the young people with rectal carcinoma.Methods:The data of 279 cases treated from January 2002 to January,of which were divided into two groups as age at onset:juvenile group (≤40 years old) and senile group (＞ 40 years old),were analyzed retrospectively.Results:The ratio for the patients with distance less than 7cm away from the anal verge acounted to 73.5％ (205/279),adenocarcinoma being the major histological type 79.6％ (222/279),so as well and middle differentiated (33.3％,93/279 ;43.0％,120/279) and radical resection of rectal carcinoma,with the liver metastasis ratio was 10％ (28/279).The ratio of juvenile rectal cancer patients was 15.1％ (42/279),and the ratio of mucinous carcinomas and signet ring cell carcinoma,poor differentiation,Dukes D staging,lymphatic metastasis,liver metastasis,palliative resection and colostomy in juvenile group was sifnifantly higher than that in senile group,except for the ratio of distance less than 7 cm away from the anal verge.Conclusion:The main clinical features of juvenile patients with rectal carcinoma are poor differentiation,high malignant degree,being prone to lymph nodes metastasis,advanced stage at onset and lower radical resection ratio.%目的:探讨青年直肠癌患者的临床病理特征.方法:回顾性分析2002年1月-2012年1月10年收治、行手术治疗的279例直肠癌患者的临床病理特征并进行回顾性分析,以40岁为界限,分为青年组(年龄≤40岁)和非青年组(年龄＞40岁).结果:肿瘤下缘距肛门距离≤7cm的比例占73.5％(205/279),病理类型以腺癌为主,占79.6％(222/279),细胞分化多呈高分化(33.3％,93/279)和中分化(43.0％,120/279),肝转移比率为10.0％ (28/279),手术方式以根治术为主,占85.7％ (239/279).青年组患者直肠癌比率为15.1％ (42/279),青年组患者黏液腺癌+印戒细胞癌比例、细胞低分化比例、Dukes D分期比例、淋巴结转移比例、肝转移比例及姑息切除手术和单纯结肠造瘘,均显著高于非青年组(P＜0.01).青年组患者肿瘤下缘距肛门距离≤7cm的比例为81.0％(34/42),高于非青年组,差异不显著(P＞0.05).结论:青年直肠癌患者具有直肠癌组织低分化、恶性程度高、易发生淋巴结转移和肝转移、就诊时分期偏晚、根治手术比例较低等临床病理特征.
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