乳腺癌组织内VEGFR-3的表达与淋巴结转移的关系

摘要

Objective:To investigate the relationship of vascular endothelial growth factor receptor-3 (VEGFR-3) with lymph vessels density (LVD) and lymph nodes metastasis.Methods:Expression of VEGFR-3 in center and periphery tissue of breast cancer in 45 cases was detected by immunohistochemical SABC method and LVD were calculated.Whether VEGFR-3 expression in breast cancer was related with age,pathological grade,tissue differentiation and lymph node metastasis or not was analyzed.Results:Expression of VEGFR-3 was correlated with lymph node metastasis (P ＜ 0.05),but not correlated with patient age,pathological grade and tissue differentiation (P ＞ 0.05).Moreover,LVD in lymph node metastasis group was higher than that in no lymph node metastasis group(P ＜0.05).Conclusion:Expression of VEGFR-3 in breast cancer tissues is related with LVD and lymph node metastasis,which predicts breast cancer lymph node metastasis.%目的:检测乳腺癌组织内血管内皮生长因子受体-3(VEGFR-3)的表达和淋巴管密度(LVD)及淋巴结转移的相关性.方法:应用免疫组化SABC法检测45例乳腺癌组织、癌旁组织中VEGFR-3的表达并计数LVD,分析其与患者年龄、临床病理学分级、组织分化程度及淋巴结转移的相关性.结果:乳腺癌组织内VEGFR-3的表达与患者年龄、临床病理学分级、组织分化程度无关(P＞0.05),而与淋巴结转移密切相关(P＜0.05),癌组织、癌旁组织有淋巴结转移组的LVD均高于无淋巴结转移组,差异有显著性(P＜0.05).结论:乳腺癌组织内VEGFR-3的表达与LVD及淋巴结转移密切相关,可作为乳腺癌淋巴结转移的预测因子.