27例原发性食管小细胞癌的临床分析

摘要

Objective:To investigate the clinical characteristics,therapy and prognosis of primary esophageal small -cell carcinoma(PESC).Methods:The clinical data of 27 cases with PESC was analyzed retrospectively,The prognostic factors were analyzed.Results:The 22.2％ patients had at least two pathological contents in 27 cases.All patients accepted combined therapy except 3 cases.The overall median survival time of these 27 cases was 14.1 months (4.6-37.2 months).The 1-,2-and 3-year overall survival rates were 65.3 ％,33.8 ％ and 9.7 ％,respectively.Univariate analysis revealed that the prognostic predictors included clinical stage and treatment modality.Multivariate analysis revealed that the clinical stage was independent prognostic factors of PESC.Conclusion:PESC maybe origin from multipotential stem cell.Chemotherapy combined with surgery and/or radiotherapy could be helpful in PESC patients.%目的:探讨原发性食管小细胞癌的临床特征、治疗和预后.方法:回顾性分析27例原发性食管小细胞癌的临床资料,分析影响预后的相关因素.结果:27例患者中混合型病理类型占22.2％(6/27),全组除3例患者仅接受单纯化疗外,其余患者均接受了手术或放疗联合化疗的综合治疗,27例患者总体中位生存期14.1个月(4.6-37.2个月),1年、2年及3年总生存率为65.3％、33.8％和9.7％.单因素分析提示临床分期、治疗方式为预后影响因素,多因素分析提示临床分期为影响预后的独立因素.结论:原发性食管小细胞癌可能起源于食管黏膜的多潜能干细胞,以化疗为主的综合治疗有望提高疗效.