血清三种肿瘤标志物检测在肺癌诊断中的应用

摘要

Objective:To investigate the clinical value of combined detection of CEA,NSE and SCC-Ag in diagnosis of lung cancer.Methods:To use electrochemical luminescence method to detect serum tumor markers of 91 patients with lung cancer(lung cancer group),42 patients with benign lesions (benign control group)and 40 cases of physical examination persons (normal control group).Results:The three kinds of serum tumor makers in lung cancer group were obviously higher than benign control group and normal control group(P ＜ 0.01).The sensitivity of CEA was 47.78％,specificity was 90.11％.The sensitivity of NSE was 46.41％,specificity was 91.01％.The sensitivity of SCC-Ag was 45.89％,specificity was 95.21％.The sensitivity of the three combined detections was 95.1％,specificity of the three combined detections was 82.0％.Conclusion:Combined detection of the three markers may effectively improve the sensitivity of lung cancer diagnosis and it has great value for early diagnosis of lung cancer.%目的:探讨血清肿瘤标志物癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、鳞癌相关抗原(SCC-Ag)检测对肺癌诊断的临床应用价值.方法:采用电化学发光法检测91例肺癌患者(肺癌组)、42例肺部良性病变患者(良性对照组)和40例健康体检者(正常对照组)血清中的3种肿瘤标志物.结果:肺癌患者血清3种肿瘤标志物水平明显高于良性对照组和正常对照组(P＜0.01).CEA敏感性为47.78％,特异性为90.11％；NSE敏感性为46.41％,特异性为91.01％；SCC-Ag敏感性为45.89％,特异性为94.98％；3项联合检测敏感性高达95.21％,特异性为82.12％.结论:联合检测血清中的CEA、NSE、SCC-Ag可显著提高肺癌诊断的敏感性,对肺癌的早期诊断有重要临床应用价值.