P-p38和uPA蛋白在大肠癌中的表达及临床意义

摘要

目的：研究P-p38和uPA蛋白的表达与大肠癌生物学行为及预后的关系。方法：应用免疫组织化学（ SP）法检测P-p38和uPA在62例大肠癌、25例大肠腺瘤及18例正常大肠黏膜组织中的表达。结果：大肠癌组织中P-p38和uPA阳性表达率分别为79.0%和74.2%，均明显高于大肠腺瘤及正常大肠黏膜组织，差异有显著统计学意义（ P<0.05）。P-p38和uPA表达与大肠癌的分化程度、淋巴结转移、Dukeˊs分期及浸润肌层的深度密切相关（ P<0.05），且两者表达成明显正相关（ P<0.05）。P-p38和uPA表达阳性者术后5年生存率明显低于阴性者，差异有显著意义（ P<0.05）。结论：P-p38和uPA 的高表达预示着大肠癌的低分化，并共同促进了肿瘤的侵袭、转移。联合检测P-p38和uPA 的表达情况对于评估大肠癌的发展及预后具有重要意义。%Objective:To study the expression of P-p38 and uPA in colorectal carcinoma and their relationship with the biological behavior and prognosis. Methods:SP immunochemical method was performed to detect the expres-sion of P-p38 and uPA in 62 cases of colorectal carcinoma,25 cases of colorectal adenomas,and 18 cases of normal colorectal tissues. Results:The positive rates of P-p38 and uPA in colorectal cancers(79. 0%,74. 2% respectively) were significantly higher than those in the colorectal adenomas and normal colorectal tissues group(P<0.05).Theex-pressions of P-p38 and uPA were closely related to pathological differentiation,lymph node metastasis,Duke's stages and the deepnessofinvasion(P<0.05).The expression of P-p38 was significantly correlated with uPA(P<0.05). The 5 years survival rates after operation in positive expression groups of P-p38 and uPA were significantly lower than those in negative expression groups. Conclusion:Overexpression of P -p38 and uPA in colorectal carcinoma were associated with poorly histological grades,cell migration,tumormetastases and poor prognosis. It is very signifi-cant to investigate the expression of P-p38 and uPA combinedly in colorectal carcinoma.