APE1 rs1760944基因多态性与中国人群癌症易感风险关系的Meta分析

摘要

目的：在DNA的碱基切除修复过程中脱嘌呤/脱嘧啶核酸内切酶1（ APE1）起至关重要的作用。流行病学研究发现 APE1 rs1760944基因多态性与致癌风险存在关联。本研究旨在评估中国人群中 APE1 rs1760944基因多态性与致癌风险之间的关系。方法：检索PubMed、ISI Web of Knowledge、中国知网数据库、万方数据库2013年11月以前符合条件的相关病例对照研究。比值比（OR）和95%可信区间（95%CI）用作评估关联强度的大小。结果：共纳入11个有关APE1 rs1760944基因型和致癌风险的病例对照研究，共计5652例癌症患者和6008例对照。分析结果显示，在任何遗传模式中，APE1 rs1760944基因多态性与降低致癌风险显著相关（纯合子对比：OR=0.71，95%CI=0.63-0.79；杂合子对比：OR=0.86，95%CI=0.79-0.94；显性模型：OR=0.80，95%CI=0.74-0.87；隐性模型：OR=0.78，95%CI=0.71-0.86）。另外，在肺癌的研究中也发现同样结论（纯合子对比：OR =0.68，95%CI=0.59-0.79；杂合子对比：OR=0.86，95%CI=0.77-0.98；显性模型：OR=0.80，95%CI=0.72-0.90；隐性模型：OR=0.77，95%CI=0.68-0.87）。结论：在中国人群中，APE1 rs1760944基因多态性可能降低癌症的易感性。%Objective:Apurinic/apyrimidinic endonuclease 1(APE1)is an essential enzyme in the base excision repair pathway. Epidemiological studies have suggested associations between APE1 rs1760944 polymorphism and cancer risk. This study was aimed to evaluate the relationship between APE1 rs1760944 polymorphism and cancer risk in Chinese population. Methods:We searched PubMed,ISI Web of Knowledge,Embase,Chinese National Knowledge Infrastructure( CNKI)databases until November 2013 to identify eligible studies. Odds ratios( ORs)and 95% confi-dence intervals( CIs)were used to estimate the strength of the associations . Results:1 1 studies from 1 0 articles on APE 1 rs 1 7 6 0 9 4 4 genotypes and cancer risk were identified ,including a total of 5 6 5 2 cancer cases and 6 0 0 8 case -free controls . Overall ,APE 1 rs 1 7 6 0 9 4 4 polymorphism was significantly associated with the decreased risk of cancer in any genetic models(homozygote comparison:OR=0. 71,95%CI=0. 63-0. 79;heterozygote compari-son:OR=0. 86,95%CI=0. 79-0. 94;dominant model:OR=0. 80,95%CI=0. 74 -0. 87 and recessive model:OR=0. 78,95%CI=0. 71-0. 86). Moreover,a significantly decreased risk was found in lung cancer studies( homozy-gote comparison:OR=0. 68,95%CI=0. 59 -0. 79;heterozygote comparison:OR=0. 86,95%CI=0. 77 -0. 98;dominant model:OR=0. 80,95%CI=0. 72-0. 90 and recessive model:OR=0. 77,95%CI=0. 68-0. 87). Con-clusion:These findings support that APE1 rs1760944 polymorphism has a possible protective effect on cancer suscep-tibility in Chinese population.