肝动脉热化疗栓塞治疗原发性肝癌疗效观察

摘要

目的：评价热化疗栓塞对原发性肝癌的中长期疗效。方法：回顾性分析1994年11月至2012年2月172例原发性肝癌行热化疗栓塞治疗患者的临床资料，应用Seldinger技术，经股动脉穿刺置管，通过肝动脉导管将微导管超选择置入肿瘤供血动脉，以碘油20ml与顺铂100mg或丝裂霉素8mg的110℃混悬液行热化疗栓塞。以门诊及电话方式随访收集资料。通过影像学检查观察肿瘤大小变化，用寿命表法计算患者累积生存率。结果：1-10年累积生存率分别为52．33％、34．88％、21．51％、12．21％、7．56％、1．74％、1．74％、1．16％、1．16％、1．16％。治疗前后有CT、B超或DSA等影像学资料对比的患者160例，完全缓解（CR）2例（1．25％），部分缓解（PR）49例（30．63％），稳定（SD）78例（48．75％），进展（PD）31例（19．38％）；有效率（CR＋PR）31．88％，肿瘤控制率（CR＋PR＋SD）80．63％。结论：热化疗栓塞是原发性肝癌的有效治疗手段。%Objective:To evaluate the long term results of thermochemoembolization for hepatocellular carcinoma. Methods:All of 172 cases of primary hepatocellular carcinoma were treated with thermochemoembolization.The re-sults were followed up and analyzed according to imagiology and the survival time.Results:Forall patients,the surviv-al rates from 1 to 10 years were 52.33%,34.88%,21.51%,12.21%,7.56%,1.74%,1.74%,1.16%,1.16%,1.16%respectively.The overall response rate was 3 1 .88%,including 2 complete remission(CR),49 partial remission(PR). The tumor control rate(CR+PR+SD)was 80.63%.Conclusion:Thermochemoembolization was an effective thera-peutic mean for primary hepatocellular carcinoma.