乳腺癌中DEC1与claudin-1的表达及其临床意义

摘要

Objective:To investigate the expression and correlation of differentiated embryonic chondrocyte ex-pressed gene 1 (DEC1 )and claudin-1 in breast cancers,and their relationships with the clinical pathological param-eters.Methods:The expression patterns and levels of DEC1 and claudin-1 were examined using immunohistochemis-try in 154 cases of breast cancer.Results:The expression of DEC1 was positively correlated with tumor grade(P=0. 002)and lymph node metastasis(P=0.048),but no significant associations were observed with patient age(P=0. 769),tumor size(P=0.216),estrogen receptor(P=0.303)or progestin receptor(P=0.127).The expression of claudin-1 was negatively correlated with estrogen receptor(P=0.006)and lymph node metastasis (P=0.025), but no significant associations were observed with patient age (P=0.538),tumor size(P=0.801),tumor grade(P=0.083)or progestin receptor(P=0.195).In addition,a significant negative correlation was found between DEC1 and claudin-1(P<0.001)in 154 cases of breast cancer.Conclusion:The expression of DEC1 was negatively corre-lated with the expression of claudin-1 and high tumor grade in breast cancer.%目的：分析DEC1（differentiated embryonic chondrocyte expressed gene 1）和claudin-1在乳腺癌组织中的表达和相关性及其与临床病理因素间的关系。方法：采用免疫组化方法检测DEC1和claudin-1在154例乳腺癌中的表达情况。结果：在154例乳腺癌中 DEC1的表达升高与乳腺癌的高分级（P＝0．002）和淋巴结转移（P＝0．048）相关，而与患者年龄（P＝0．769）、肿瘤大小（P＝0．216）、患者的雌激素水平（P＝0．303）及孕激素水平（P＝0．127）无相关性。而claudin-1的表达缺失与患者的雌激素水平（P＝0．006）和淋巴结转移（P＝0．025）相关，而与患者年龄（P＝0．538）、肿瘤大小（P＝0．801）、肿瘤的分级（P＝0．083）及患者的孕激素水平（P＝0．195）无相关性。并且DEC1在乳腺癌中的表达与claudin-1的表达显著负相关（P＜0．001）。结论：乳腺癌中DEC1的表达与claudin-1的表达负相关，并与肿瘤的高分级相关。