前列腺癌术后 Gleason 分级与 PSA、P504s、Ki -67蛋白表达相关性分析

摘要

To study the Gleason histologic grading of prostate carcinoma in relation to the expression of PSA,P504s and Ki - 67 in prostatic carcinoma tissue. Methods:The expressions of PSA,P504s and Ki - 67 were de-tected with immunohistochemical SP method in 45 cases of prostatic cancer after operation. Results:The higher the Gleason histologic grading of prostate carcinoma,the weaker the PSA lever(P ﹤ 0. 05),the highter the Ki - 67 lever (P ﹤ 0. 05). The strong expression of P504s,no correlation to the Gleason histologic grading(P ﹥ 0. 05). Conclu-sion:The weaker PSA and the higher Ki - 67 expression,the worse of prostate cancer tissue differentiation degree. P504s strong expression in prostate cancer,can be applied in diagnosis,no obvious correlation with prognosis.%目的：探讨前列腺癌 Gleason 分级评分与 PSA、P504s、Ki -67蛋白免疫组化表达的关系。方法：采用免疫组化 SP 法检测45例前列腺癌患者术后石蜡包埋组织中 PSA、P504s、Ki -67的表达，并根据 HE 切片进行 Gleason 分级评分。结果：前列腺癌 Gleason 分值越高，PSA 阳性表达越弱（P ﹤0.05），Ki -67阳性表达越强（P ﹤0.05）；P504s 强表达，与 Gleason 评分无相关性（P ﹥0.05）。结论：PSA 表达越弱、Ki -67表达越强，前列腺癌组织分化程度越差，预后越差。P504s 在前列腺癌中强表达，可应用于诊断，与预后无明显相关性。