VEGF-C/VEGFR-3及SDF-1/CXCR4信号途径与肿瘤淋巴管新生的关系

摘要

Lymphangiogenesis is closely correlated with lymphatic metastasis in cancer. In recent years,the research on mechanism of lymphangiogenesis in carcinoma tissues has gradually become a hotspot. A large number of studies have demonstated that VEGF - C/ VEGFR - 3 and SDF - 1 / CXCR4 signaling pathways play a critical role in tumor -induced lymphangiogenesis. This paper reviews the advances in the research on mechanism of lymphangiogenesis in carcinoma tissues,the correlation between lymphangiogenesis and lymphatic metastasis in cancer,the role of VEGF -C/ VEGFR - 3 and SDF - 1 / CXCR4 signaling pathways in tumor - induced lymphangiogenesis and the clinical re-search on anti - lymphangiogenic therapy in cancer.%肿瘤新生淋巴管与肿瘤细胞的淋巴转移密切相关，近年来肿瘤淋巴管新生机制的研究逐渐成为热点。大量研究发现 VEGF - C/ VEGFR -3及 SDF -1/ CXCR4信号途径在肿瘤淋巴管新生中起着重要作用。本文综述了肿瘤淋巴管新生的机制及其与肿瘤淋巴结转移的关系、VEGF - C/ VEGFR -3及 SDF -1/ CX-CR4信号途径在肿瘤淋巴管新生中的作用及抗肿瘤淋巴管新生的临床应用研究。