三阴性乳腺癌中CK5/6表达的研究

摘要

Objective:To investigate the expression of CK5/6 in triple negative breast cancer and the relation with the clinical and pathological feature. Methods:The expression of CK5/6 in 374 breast cancer samples(318 non-tri-ple negative and 56 triple negative breast cancer)were analyzed by immunohistochemistry. Results:62. 50% of triple negative breast cancer was positive for CK5/6 ,and 12. 89% of non-triple negative breast cancer was positive( P<0. 01). The expression of CK5/6 in TNBC has non-relationship with the menopausal status,lymph nodes metasta-sis,tumor size and neoplasm staging(P<0. 05),but had significant difference with the histological grade(P<0. 01). Conclusion:The expression of CK5/6 in TNBC is higher than in non-TNBC. CK5/6 reflects the origins of breast tumors,are clearly related with the histological grade.%目的：探讨CK5/6在三阴性乳腺癌中的表达特点及其与临床病理表现的相关性。方法：免疫组织化学方法检测374例乳腺癌标本（318例非三阴性乳腺癌，56例三阴性乳腺癌）中CK5/6的表达情况。探讨其在三阴性及非三阴性乳腺癌中的表达差异。结果：在三阴性乳腺癌病例中，CK5/6阳性表达率为62.50％（35/56）；在非三阴性乳腺癌病例中，CK5/6阳性表达率为12.89％（41/318），两者相比较（ P＜0.01），有统计学差异。在以组织学分级（组织学分级G1级和G2级之间比较）为指标进行的分组中CK5/6的表达有统计学差异（ P＜0.05），以患者月经状况、肿瘤大小、肿瘤分期（ I-Ⅱ期与Ⅲ-Ⅳ期之间比较）和淋巴结转移情况作为指标进行的分组中表达均无统计学差异（P＞0.05）。结论：CK5/6在三阴型乳腺癌中过表达，是一个相对独立的反映乳腺肿瘤起源特点的免疫组化指标，与组织学分级有明显关系。