云南省乳腺癌基线特征分析

摘要

Objective:To study the baseline characteristics of breast cancer in Yunnan Province. Methods:Col-lected 1862 cases confirmed to be breast cancer by pathology. Results:Patients were aged in 21 to 78,the average age was(48. 23 ± 10. 59)years old,the peak age of onset was 40-49 years old. According to the age<40 and age≥40 years old,to analyze the national different ,production history ,onset time ,pathological classification ,staging ,and molecular classification,ER,PR,CerbB2,p53,Ki67 expression. Except production history(P<0. 001)and PR(P=0. 025)had statistical difference,other had no statistical difference(P>0. 05). Predominantly invasive nonspecific carcinoma in pathological classification,with 1523 cases,accounting for 81. 8%;Pathological staging Ⅱ period pa-tients,with 916 cases,accounting for 49. 2%. Main molecular classification was Luminal B patients,with 1260 cases, accounting for 67. 7%. According to the stratified analysis of different cultural levels,the breast cancer patients be-tween the ages of different cultural levels,production history,pathological staging expression difference was statistically significant(P<0. 05),while other factors had no statistically significant difference(P >0. 05). Conclusion:The difference between Han nationality and ethnic minorities breast cancer patients in Yunnan Province has not been found. The clinical feature of breast cancer may have relationship with education level.%目的：了解云南省肿瘤医院收治的乳腺癌患者基线特点。方法：收集2011年1月-2012年12月云南省肿瘤医院乳腺病科收治的经病理确诊为乳腺癌的所有初诊患者，共计1862例，对其年龄、病理分型、分期及分子分型构成等情况进行分析。结果：患者年龄21-78岁，平均年龄（48.23±10.59）岁。发病高峰年龄为40-49岁，按年龄＜40和年龄≥40岁分为2组，分析不同年龄组民族、生产史、发病时间、病理分型、分期、分子分型、ER、PR、CerbB2、p53及Ki67的表达情况。除生产史（P＜0.001）和PR（P＝0.025）差异有统计学意义外，其余差异均无统计学意义（P＞0.05）。病理分型以浸润性非特殊癌为主，共1523例，占81.8％。临床分期以Ⅱ期患者为主，共916例，占49.2％；Ⅰ期620例，占33.3％；Ⅲ期294例，占15.8％；Ⅳ期32例，占1.7％。分子分型以Luminal B型患者为主，共1260例，占67.7％。按不同文化程度文盲、小学、初中、高中/中专、大专及以上分层分析，不同文化程度乳腺癌患者之间的年龄、生产史及病理分期的表达情况差异有统计学意义（ P＜0.05）。而不同文化程度乳腺癌患者之间的病理类型、分子分型、ER、PR、CerbB2、p53及Ki67表达等情况差异无统计学意义（ P＞0.05）。结论：云南省肿瘤医院收治的乳腺癌患者发病高峰年龄、发病主要病理类型、临床分期与国内其他报道相似，未发现少数民族和汉族乳腺癌患者之间临床病理特征有差异。文化程度所产生不同认知能力可能会影响乳腺癌的发生发展，文化程度高的患者临床分期相对较早。