三乙醇胺乳膏防治急性放射性皮炎的疗效观察

摘要

目的：观察三乙醇胺乳膏预防急性放射性皮炎的临床效果。方法：将放射治疗的86例鼻咽癌和乳腺癌根治术或改良根治术后需行辅助性放射治疗的病人随机分为用药组（45例）和对照组（41例）。用药组在放射治疗开始即给予三乙醇胺乳膏涂擦，直至放疗结束，发生湿性皮炎后局部继续涂擦三乙醇胺乳膏；对照组保持照射野皮肤干燥、清洁，不予任何药物外涂，发生湿性皮炎后局部涂擦烫伤油。结果：用药组Ⅱ级及以上急性放射性皮炎的发生率明显低于对照组（ P＜0.05），存在统计学差异。对照组有1例发生Ⅳ级急性放射性皮炎，而用药组无Ⅳ级急性放射性皮炎发生。且用药组急性放射性皮炎发生时间明显晚于对照组，差异有统计学意义（P＜0.05）。同时用药组明显缩短急性放射性皮炎愈合时间（P＜0.05）。结论：三乙醇胺乳膏能有效地防治急性放射性皮炎。%Objective:To evaluate the clinical efficacy of trolamine cream in the prevention and treatment of acute radioactive dermatitis with nasopharyngeal carcinoma and breast carcinoma. Methods:All 86 patients with nasopha-ryngeal carcinoma and postoperative breast carcinoma accepted radiotherapy were devided into two groups randomly. Treatment group(45 cases)was given trolamine cream since the beginning of radiotherapy while the other 41 cases were not given this medication but general skin care program as control group. Results:The rate of radiation dermatitis of grade Ⅱ was lower in the treatment group than in the control group(P<0. 05). One case developed radiation der-matitis of gradeⅣ in the control group,none in the treatment group. The time of radiation dermatitis was latter in the treatment group than control group(P<0. 05). Radiation dermatitis healling time was shorter in the treatment group than the control group(P<0. 05). Conclusion:Trolamine cream can prevent and treat acute radioactive dermatitis.