联合检测CEA、CA19-9在D2胃癌术后随访中的价值

摘要

Objective:To investigate the clinical value of combined detection of serum tumor markers CEA and CA19-9 in the follow-up of postoperative gastric cancer. Methods:The CEA and CA19-9 were detected with flu-oroimmunoassay in 271 postoperative gastric cancer patients. According to the results,the patients were classified into four groups:CEA( -)/CA19-9( -),CEA( ﹢)/CA19-9( -),CEA( -)/CA19-9( ﹢)and CEA( ﹢)/CA19-9( ﹢). The survival rates were calculated by Kaplan-meier method,differences between survival curves were ex-amined with Log-rank test,and univariate analysis was performed using Chi-square test. Results:When combined detection with CEA and CA19-9,both as the positive group patient survival was much lower than the single positive group. The patients survival was lower in CEA( -)/CA19-9( ﹢)group compared with CEA( ﹢)/CA19-9( -) group. Differences were statistically significant(P<0. 05). Conclusion:Combined detection of serum tumor markers CEA and CA19-9 in the follow-up of postoperative gastric cancer,with CA-199 positive suggests poorer prognosis.%目的：探讨联合检测血清肿瘤标志物癌胚抗原（ CEA）和糖类抗原19-9（ CA19-9）在D2胃癌术后患者随访中的应用价值。方法：采集271例D2胃癌术后病人血清，利用免疫荧光分析法检测血清中CEA和CA19-9含量，并根据检验结果划分为CEA（-）/CA19-9（-）、CEA（﹢）/CA19-9（-）、CEA（-）/CA19-9（﹢）和CEA（﹢）/CA19-9（﹢）四个组。采用Kaplan-meier法进行生存率分析，利用Log-rank检验进行统计学差异性比较，χ2检验进行组间单因素分析。结果：两种肿瘤标志物CEA和CA19-9的联合检测时，两个同时为阳性组患者生存期远远低于单一阳性组；CEA（﹢）/CA19-9（-）组与CEA（-）/CA19-9（﹢）组比较，CEA（-）/CA19-9（﹢）组患者生存期要低于对照组，具有统计学差异（ P＜0.05）。结论：联合检测血清肿瘤标志物CEA和CA19-9在D2胃癌术后患者随访中，CA19-9阳性者提示更差的预后。