KiSS-1基因与肿瘤关系的研究进展

摘要

KiSS-1 has important roles in physiology and cancer development,especially recent studies suggests that aberrant expression of KiSS-1 was found in many cancers,such as breast cancer,melanoma which proposed to inhibit cancer cell motility. We review the gene of KiSS-1 and its relationship with tumors.%KiSS-1蛋白在正常生理发育过程和肿瘤发生发展中发挥着重要作用，尤其是近年来研究发现KiSS-1基因在多种肿瘤中异常表达，如乳腺癌、黑色素瘤等，提示KiSS-1参与抑制肿瘤细胞迁移。本文就KiSS-1的结构功能及其与肿瘤的关系做一综述。