目的：回顾性分析三氧化二砷联合 LD －HA 治疗难治性非 M3急性非淋巴细胞白血病的疗效及不良反应。方法：应用三氧化二砷（0．15mg·kg-1·d-1，d1～5，d8～12）＋LD －HA（高三尖杉酯碱1mg／d，阿糖胞苷25mg，2次／d，d1～14治疗。ANC（中性粒细胞计数）＜1．0×109／L 时使用粒细胞集落刺激因子（G －CSF）5μg· kg-1·d-1，直至 ANC ＞1．0×109／L。结果：一个疗程的总有效率达91．1％，其中 CR 32例（71．1％），PR 9例（20％），NR 4例（8．9％）。不良反应轻微。结论：三氧化二砷联合 LD －HA 治疗难治性非 M3急性非淋巴细胞白血病安全有效。%Objective:To observe the therapeutic outcome and adversere effect of the combined As2 O3 with low -dose homoharringtonine -cytarabine(LD -HA)in the treatment of refractory or relapsed non -M3 acute non -lym-phocytic leukemia.Methods:All the patients was treated with As2 O3 (0.15mg·kg-1 ·d-1 ,d1 ~5 ,d8 ~12 )and LD -HA with homoharringtonine 1mg/d and Ara -C 25mg,per 12h,d1 ~14 .Granulocyte colony -stimulating factor(G -CSF,5μg·kg-1 ·d-1 )was used when the absolute neutrophil count were counted less than 1.0 ×109 /L.Results:After one course of therapy,total efficiency rate of relapsed non -M3 acute non -lymphocytic leukemia was 91.1%, in which the complete remission (CR)were 32 cases(71.1%),partial response were 9 cases(20%),non -remis-sion were 4 cases(8.9%),without any great side effect.Conclusion:The combination of As2 O3 and LD -HA scheme had higher CR rate and fewer adverse action in the treatment of refractory or relapsed acute non -lymphocytic leuke-mia patients.
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