胃癌患者血清 CA72－4、CEA 及 CA19－9水平及其与临床病理特征的相关性

摘要

目的：探讨血清 CA72－4、CEA 及 CA19－9水平与胃癌患者病理特征的相关性。方法：选择2011年6月－2013年3月收治的86例胃癌患者，56例胃良性肿瘤患者，60例普通胃病患者，比较三组患者 CA72－4、CA19－9和 CEA 水平；CA72－4、CA19－9和 CEA 单项检测及联合检测胃癌患者的阳性率；CA72－4、CA19－9和 CEA 水平与胃癌病理特征的关系。结果：胃癌组患者血清 CA72－4、CA19－9和 CEA 水平均高于胃良性肿瘤组患者（P ＜0．05），胃癌良性组患者均高于对照组（P ＜0．05）；三种胃癌肿瘤标志物中 CA72－4诊断胃癌的阳性率最高，肿瘤3项标志物的阳性检测率要显著高于单项 CA72－4、CA19－9、CEA 的阳性检出率（P＜0．05）；肿瘤越大、TNM分期越高，CA72－4、CA19－9和 CEA 水平越高。结论：采用 CA72－4、CA19－9和CEA 联合检测是诊断胃癌比较理想的组合。CA72－4、CA19－9和 CEA 水平的变化可以反应胃癌患者的病理特征。%Objective:To investigate serum CA72 -4,CEA and CA19 -9 levels and pathological features of pa-tients with gastric cancer.Methods:In 86 cases of gastric cancer CA72 -4,CA19 -9 and CEA levels were tested and pathological features with gastric cancer were analyzed.Results:In the serum of patients with gastric cancer CA72 -4,CA19 -9 and CEA levels were significantly higher than the group of patients with benign gastric diseases(P <0.05).The positive rats of combined three gastric tumor markers was significantly higher than single one(P <0.05). The larger of the tumor,the later of TNMstage,the higher of CA72 -4,CA19 -9 and CEA levels.Conclusion:CA72-4,CA19 -9 and CEA combined detection is an ideal marker in diagnosis of gastric cancer.