血小板计数在判断初诊乳腺癌患者预后中的意义

摘要

目的：研究血小板计数在判断初诊乳腺癌患者预后中的意义。方法：回顾性分析68例乳腺癌患者初诊时的血小板计数及其他临床信息，采用 SPSS 16．0对血小板计数与其他临床资料之间的相关性进行分析。结果：68例乳腺癌患者中，Ⅰ期10例、Ⅱ期22例、Ⅲ期18例、Ⅳ18例，淋巴结转移33例、远处转移18例。3年生存率39．71％，5年生存率19．11％，单因素分析、t 检验及相关性分析表明血小板计数与生存之间存在相关性（r ＝－0．597，P ＜0．01）；血小板计数与临床分期、淋巴结转移及远处转移之间均有相关性（P ＜0．01）。雌激素受体（estrogen receptor，ER）状态以及发病年龄与患者的生存时间之间无统计学差异（P ＞0．05）。结论：初诊乳腺癌患者血小板的增高与其生存时间之间呈负相关性，血小板计数的增高对初诊患者不良预后有预测作用。%Objective:To investigate the correlation between platelet count and prognosis in patients with newly di-agnosed breast cancer.Methods:Platelet count and other clinical information were measured in 68 patients with newly diagnosed breast cancer.A retrospective analysis of the relationship between the platelet count and other clinical char-acteristics was done with SPSS 16.0.Results:Patients in stage Ⅰ -Ⅳ were 10,22,18,and 18.Thirty three patients had lymph node metastasis,and 18 patients had distant metastasis.The 3 -year and 5 -year survival rates were 39.71% and 19.11% respectively.One -way anova,t test and Pearson correlation indicated that platelet count had an association with cancer -specific survival(r =-0.597,P <0.01).Platelet count also had relations with clinical stage,distant metastasis and lymph node metastasis(P <0.01).Nostatistically significant differences were found be-tween platelet,age and estrogen receptor status(P >0.05).Conclusion:The platelet count is considered to be an useful predictor of worse survival for patients with breast cancer.