头颈部肿瘤化疗引起口腔黏膜炎的危险因素分析

摘要

Objective:To investigate the risk factors affecting the head and neck cancer chemotherapy -induced o-ral mucositis.Methods:All 315 cases with head and neck cancer receiving chemotherapy were analyzed to identify the cause of oral mucosa inflammation.Results:With increasing age,the incidence of oral mucositis have gradually in-creased,also patient with history of smoking and oral mucosa denture.Gender had no effect on the incidence of oral mucosal inflammation.Oral pH,white blood cell count and oral mucosa inflammation had no significant relationship (P <0.05),including 5 -FU,oral diseases,prevention of mouth antibiotics,hospital stay were related to the oral mu-cositis(P <0.05).Conclusion:Age,oral diseases,including 5 -FU,antibiotics,days of hospitalization,anxiety and depression in patients with head and neck cancer are related with chemotherapy -induced inflammation of the oral mucosa.%目的：探讨影响头颈部肿瘤化疗引起口腔黏膜炎的危险因素。方法：研究对象为2011年5月－2013年6月我市三甲医院315例头颈部接受化疗的肿瘤患者，分析引起头颈部肿瘤化疗患者口腔黏膜炎症的影响因素。结果：随着患者年龄的增大，口腔黏膜炎的发病率有逐渐升高的趋势，有吸烟史的患者以及有义齿的患者口腔黏膜的发病率较高，性别对于口腔黏膜炎症的发病率没有影响；口腔 pH、白细胞数与患者口腔黏膜炎症的发病率没有显著性的关系（P ＜0．05），含5－FU、口腔疾患、预防漱口等与患者口腔黏膜炎症的发病率有显著性的关系（P ＜0．05）；具有恶心、呕吐患者的口腔黏膜炎症的发病率较高，使用抗生素患者的口腔黏膜炎症的发病率要显著性低于未使用抗生素的患者，具有焦虑抑郁的患者发生口腔黏膜炎症的发病率会显著性的增加，随着住院天数的增加，患者发生口腔黏膜炎症的发病率会显著性的升高，两组比较均具有显著性的差异（P ＜0．05）。结论：年龄、口腔疾患、含5－FU、抗生素、住院天数、焦虑抑郁等与头颈部的肿瘤化疗患者引起口腔黏膜炎症的发生率有一定的相关性。