替莫唑胺对比传统化疗药治疗高级别脑胶质瘤的临床疗效

摘要

Objective:To study the effect of traditional chemotherapy and temozolomide for the treatment of high-grade gliomas. Methods:All 100 cases of high-grade brain glioma patients,were divided into three groups:Group A 35 patients received temozolomide treatment,31 cases of group B were given semustine therapy,group C 34 patients received treatment nimustine. Results:In group A complete remission ,partial remission rate and the total effective rate were 8. 57%,37. 14% and 45. 71%,respectively. In group B 0,12. 90% and 12. 90%,group C were 2. 94%, 23. 53% and 26. 47%,the treatment effect of A was significantly better than in group B,C groups,the difference was statistically significant(P<0. 05). Conclusion:Compared with other traditional chemotherapy drugs,temozolomide for the treatment of high-grade gliomas is better,the complete remission rate can be significantly improved.%目的：探讨与其他传统化疗药物相比，替莫唑胺用于治疗高级别脑胶质瘤的临床效果。方法：选取高级别脑胶质瘤患者100例，根据其治疗方案不同将其分为3组。A组35例，给予替莫唑胺治疗；B组31例，给予司莫司汀治疗；C组34例，给予尼莫司汀治疗。对三组患者治疗效果进行评价。结果：A组患者完全缓解率、部分缓解率以及总有效率分别为8.57％、37.14％和45.71％，B组患者分别为0、12.90％和12.90％，C组患者分别为2.94％、23.53％和26.47％，A组患者治疗效果明显优于 B、C 两组，差异有统计学意义（ P<0.05）。结论：与其他传统化疗药物相比，替莫唑胺用于治疗高级别脑胶质瘤效果更好，患者的完全缓解率、总有效率均可得到明显提高，在条件允许的情况下可以将替莫唑胺作为首选的药物进行应用。