肺腺癌骨转移患者血清肿瘤标志物的表达及意义

摘要

目的：探讨血清肿瘤标志物在晚期肺腺癌患者中的表达情况。方法：对2010年1月到2013年12月在我院住院治疗的64例肺腺癌骨转移患者的血清肿瘤标志物，进行回顾性分析，计算不同肿瘤标志物的阳性表达情况。结果：CEA、CA199、CA242、CA125、NSE和CY211在晚期肺腺癌中的阳性率分别为65.6％、40.6％、25.0％、73.4％、12.5％和43.8％，各组间阳性表达有统计学差异。联合检测的阳性率为90.6％。结论：不同肿瘤标志物在晚期肺癌骨转移患者血清中的表达是有差异的。CEA、CA199、CA125和CY211是肺腺癌诊断中较可靠的肿瘤标志指标。目前的血清肿瘤标志物检测对晚期肺癌诊断仍有一定的假阴性率，需结合临床及影像学检查进行综合判断。%Objective:To investigate the serum tumor markers expression in patients with advanced lung adenocar-cinoma. Methods:The serum tumor markers of 64 cases with lung adenocarcinoma patients with bone metastases from January 2010 to December 2013,were analyzed,and calculated the positive expression of different tumor markers ret-rospectively. Results:CEA,CA199,CA242,CA125,NSE and CY211 positive rates in advanced lung adenocarcinoma were 65. 6%,40. 6%,25. 0%,73. 4%,12. 5% and 43. 8%. There was statistically difference of positive expression between each group. Combined detection positive rate was 90. 6%. Conclusion:The tumor markers in the advanced lung cancer were differently expressed. CEA,CA199,CA125 and CY211 are better tumor markers in diagnosis of pa-tients with lung adenocarcinoma. There was certain false negative rate of the current serum tumor markers,and the combined detection is difficult to completely avoid false negatives.